<p>The <a href="https://bluejaysnation.com/">Toronto Blue Jays</a> will open a three-game series against the Boston Red Sox at Fenway Park on Friday night.</p>
<p>Toronto is coming off a series victory over the Guardians in Cleveland, taking two of three games, including a 6-0 victory on Thursday afternoon.</p>
<p>Boston, meanwhile, has lost five straight games and is quickly falling out of the playoff picture in the American League.</p>
<p>Let&#8217;s take a look at the odds for Friday&#8217;s series opener between the Blue Jays and Red Sox, courtesy of <a href="https://www.on.bet365.ca/olp/open-account?affiliate=365_03431249&amp;utm_medium=affiliate&amp;utm_source=139656&amp;utm_campaign=365_03431249">bet365</a>.</p>
<h2>Blue Jays vs. Red Sox odds</h2>
<table style="border-collapse: collapse; width: 100%;" border="1">
<tbody>
<tr>
<td style="width: 50%;">Blue Jays moneyline odds</td>
<td style="width: 50%;">-105</td>
</tr>
<tr>
<td style="width: 50%;">Red Sox moneyline odds</td>
<td style="width: 50%;">-115</td>
</tr>
<tr>
<td style="width: 50%;">Runline odds</td>
<td style="width: 50%;">Red Sox -1.5 (+180), Blue Jays +1.5 (-220)</td>
</tr>
<tr>
<td style="width: 50%;">Game total</td>
<td style="width: 50%;">Over 8.5 runs (-120), Under 8.5 (+100)</td>
</tr>
<tr>
<td style="width: 50%;">Date/Time</td>
<td style="width: 50%;">June 27, 7:10 p.m. ET</td>
</tr>
</tbody>
</table>
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<h2>About the Blue Jays (43-37 SU, 47-33 ATS, 42-36-2 o/u)</h2>
<p>The Blue Jays&#8217; 6-0 win on Thursday came at a cost, as slugger Vladimir Guerrero Jr. was forced to exit after getting hit by a pitch on his right arm. He underwent x-rays, which came back negative for a fracture, but he was seen struggling to hold a bat in the dugout. He&#8217;s considered day-to-day, and it wouldn&#8217;t be surprising if he&#8217;s excluded from the lineup on Friday night, which could potentially be a huge blow for the Blue Jays as Vladdy boasts a career .353/.432/.600 slash line with a 1.032 OPS at Fenway Park.</p>
<p>Otherwise, the Blue Jays are in great shape, trailing the New York Yankees by only three games for the AL East lead. They enter this series sitting comfortably in the AL&#8217;s second wild-card spot with a two-game lead over the Seattle Mariners, who are holding down the final playoff position.</p>
<p>Toronto took two of three from Boston at the Rogers Centre at the end of April. Two of those three games played over the total.</p>
<h2>About the Red Sox (40-42 SU, 41-41 ATS, 37-44-1 o/u)</h2>
<p>The Red Sox are 3-6 since trading slugger Rafael Devers to the San Francisco Giants, and they&#8217;ll need to start winning some ball games consistently to remain in the AL playoff picture.</p>
<p>They&#8217;re returning home after a nine-game road trip on the West Coast, which didn&#8217;t end well with five consecutive losses to the Giants and the Los Angeles Angels. They&#8217;ve been outscored 29-16 during the losing skid, scoring two runs or less per game three times in that span.</p>
<p>The club recently promoted top prospects Marcelo Mayer and Roman Anthony in an attempt to spark the offence, but both players have struggled since being called up to the big leagues. Mayer is slashing .208/.262/.429 through his first 77 career at-bats, although he has bashed four homers, and Anthony owns a miserable .114/.291/.227 slash line through his first 15 games.</p>
<p>Another one of Boston&#8217;s top prospects, Kristian Campbell, was recently demoted to the minors due to a prolonged slump after a great start to the season.</p>
<h2>Probable starting pitchers</h2>
<p><strong>Toronto:</strong> RHP Jose Berrios (3-3, 3.51 ERA, 7.67 K/9)</p>
<p><a href="https://bluejaysnation.com/news/overshadowed-offences-12-run-explosion-jose-berrios-best-performance-2025-against-struggling-as">Berrios</a>, who has allowed one earned run or fewer in four of his last five starts, held the Chicago White Sox to a single run over 7 2/3 innings the last time he took the hill. He also was solid in his only previous start against Boston this season, holding the Red Sox to two runs over 6 2/3 innings while striking out eight back on May 1. The veteran right-hander has been electric in his 10 night starts this season, recording a 2.37 ERA while holding opponents to a .201 batting average (5.50 ERA, .289 opponents&#8217; batting average in day games).</p>
<p><strong>Boston:</strong> RHP Brayan Bello (3-2, 3.31 ERA, 7.03 K/9)</p>
<p>Bello has been one of Boston&#8217;s most reliable starters this season, and he appears to be really rounding into form this month, as evidenced by his 2.49 ERA over his last four starts. He turned in his best start of the season on June 15 against the New York Yankees, holding them to three hits and no runs over seven innings, and he followed that up by only allowing a single earned run over six innings against the Giants in his last start. Bello&#8217;s 55% ground-ball rate ranks in the 91st percentile in baseball, as he throws an effective sinker and sweeper to keep the ball out of the air.</p>
<h2>Notable injuries</h2>
<p>Pitchers Ryan Burr (shoulder), Bowden Francis (shoulder), and Yimi Garcia (shoulder) are all on the injured list for Toronto. Outfielders Daulton Varsho (hamstring) and Anthony Santander (shoulder) are also on the shelf. As previously mentioned, Guerrero Jr. is day-to-day with an arm contusion.</p>
<p>Pitchers Tanner Houck (elbow), Jordan Hicks (toe), Kutter Crawford (wrist), Justin Slaten (shoulder), Hunter Dobbins (elbow), and Liam Hendriks (hip) are on the injured list for Boston. Third baseman Alex Bregman (quad), outfielder Masataka Yoshida (shoulder), and first baseman Triston Casas (knee) are also on the shelf.</p>
<h2>Weather</h2>
<p>Forecasts are calling for evening temperatures around 19 C under cloudy skies in Boston. Winds will blow from right field to left field at 8 mph.</p>
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<h2>Blue Jays vs. Red Sox betting trends</h2>
<ul>
<li>The under is 7-3 in the past 10 meetings between these two teams.</li>
<li>The under is 10-4 in Boston&#8217;s last 14 games.</li>
<li>The Blue Jays have hit the team total over in 18 of their last 25 games.</li>
<li>The Red Sox are 5-0 SU in their last five home games.</li>
</ul>
<h2>Blue Jays vs. Red Sox player prop trends</h2>
<ul>
<li>Bello has struck out four or more batters in four straight starts and seven of his last 10. He&#8217;s around -115 to record over 3.5 strikeouts.</li>
<li>George Springer and Myles Straw are both bringing five-game hitting streaks into action. Springer is -215 to get a hit; Straw is -155.</li>
<li>Bello has recorded over 17.5 outs in each of his last four starts. He&#8217;s -150 to do it again Friday.</li>
<li>Berrios has allowed under 5.5 hits in seven of his last 10 starts, averaging 4.9 hits allowed per game during that span. He&#8217;s -110 to come under that number against the Red Sox on Friday.</li>
<li>Guerrero Jr. has incredible splits against Bello, boasting a .417 batting average with a 1.272 OPS in 24 at-bats against the right-hander. Vladdy also has two homers and 10 RBIs against Bello, but it&#8217;s not a given he&#8217;ll be in the lineup Friday due to his injury. Even if he does play, he might not be as effective at the plate if his arm is bothering him.</li>
</ul>
<h2>Blue Jays vs. Red Sox best bet</h2>
<ul>
<li><strong>Jarren Duran over 1.5 hits: +180 for one unit (best odds @ FanDuel)</strong>. Duran has been relatively quiet at the plate lately, but this seems like an excellent opportunity for him to break out against Berrios, a pitcher he&#8217;s had a ton of success hitting against. Duran owns a .476 batting average and 1.619 OPS with three homers in 21 career at-bats against the righty, and he&#8217;s recorded multiple hits in 38% of his games at Fenway Park this season. That means we&#8217;re getting good value in this spot at +180 (35.7% implied odds), especially considering the batter vs. starting pitcher splits.</li>
</ul>


Boston Red Sox center fielder Ceddanne Rafaela (3) steals second base against Toronto Blue Jays second baseman Andres Gimenez (0) during the second inning at Rogers Centre.

The <a href="https://bluejaysnation.com/">Toronto Blue Jays</a> will open a three-game series against the Boston Red Sox at Fenway Park on Friday night.

Toronto is coming off a series victory over the Guardians in Cleveland, taking two of three games, including a 6-0 victory on Thursday afternoon.

Boston, meanwhile, has lost five straight games and is quickly falling out of the playoff picture in the American League.

Let's take a look at the odds for Friday's series opener between the Blue Jays and Red Sox, courtesy of <a href="https://www.on.bet365.ca/olp/open-account?affiliate=365_03431249&amp;utm_medium=affiliate&amp;utm_source=139656&amp;utm_campaign=365_03431249">bet365</a>.
<h2>Blue Jays vs. Red Sox odds</h2>
<table style="border-collapse: collapse; width: 100%;" border="1">
<tbody>
<tr>
<td style="width: 50%;">Blue Jays moneyline odds</td>
<td style="width: 50%;">-105</td>
</tr>
<tr>
<td style="width: 50%;">Red Sox moneyline odds</td>
<td style="width: 50%;">-115</td>
</tr>
<tr>
<td style="width: 50%;">Runline odds</td>
<td style="width: 50%;">Red Sox -1.5 (+180), Blue Jays +1.5 (-220)</td>
</tr>
<tr>
<td style="width: 50%;">Game total</td>
<td style="width: 50%;">Over 8.5 runs (-120), Under 8.5 (+100)</td>
</tr>
<tr>
<td style="width: 50%;">Date/Time</td>
<td style="width: 50%;">June 27, 7:10 p.m. ET</td>
</tr>
</tbody>
</table>
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<h2>About the Blue Jays (43-37 SU, 47-33 ATS, 42-36-2 o/u)</h2>
The Blue Jays' 6-0 win on Thursday came at a cost, as slugger Vladimir Guerrero Jr. was forced to exit after getting hit by a pitch on his right arm. He underwent x-rays, which came back negative for a fracture, but he was seen struggling to hold a bat in the dugout. He's considered day-to-day, and it wouldn't be surprising if he's excluded from the lineup on Friday night, which could potentially be a huge blow for the Blue Jays as Vladdy boasts a career .353/.432/.600 slash line with a 1.032 OPS at Fenway Park.

Otherwise, the Blue Jays are in great shape, trailing the New York Yankees by only three games for the AL East lead. They enter this series sitting comfortably in the AL's second wild-card spot with a two-game lead over the Seattle Mariners, who are holding down the final playoff position.

Toronto took two of three from Boston at the Rogers Centre at the end of April. Two of those three games played over the total.
<h2>About the Red Sox (40-42 SU, 41-41 ATS, 37-44-1 o/u)</h2>
The Red Sox are 3-6 since trading slugger Rafael Devers to the San Francisco Giants, and they'll need to start winning some ball games consistently to remain in the AL playoff picture.

They're returning home after a nine-game road trip on the West Coast, which didn't end well with five consecutive losses to the Giants and the Los Angeles Angels. They've been outscored 29-16 during the losing skid, scoring two runs or less per game three times in that span.

The club recently promoted top prospects Marcelo Mayer and Roman Anthony in an attempt to spark the offence, but both players have struggled since being called up to the big leagues. Mayer is slashing .208/.262/.429 through his first 77 career at-bats, although he has bashed four homers, and Anthony owns a miserable .114/.291/.227 slash line through his first 15 games.

Another one of Boston's top prospects, Kristian Campbell, was recently demoted to the minors due to a prolonged slump after a great start to the season.
<h2>Probable starting pitchers</h2>
<strong>Toronto:</strong> RHP Jose Berrios (3-3, 3.51 ERA, 7.67 K/9)

<a href="https://bluejaysnation.com/news/overshadowed-offences-12-run-explosion-jose-berrios-best-performance-2025-against-struggling-as">Berrios</a>, who has allowed one earned run or fewer in four of his last five starts, held the Chicago White Sox to a single run over 7 2/3 innings the last time he took the hill. He also was solid in his only previous start against Boston this season, holding the Red Sox to two runs over 6 2/3 innings while striking out eight back on May 1. The veteran right-hander has been electric in his 10 night starts this season, recording a 2.37 ERA while holding opponents to a .201 batting average (5.50 ERA, .289 opponents' batting average in day games).

<strong>Boston:</strong> RHP Brayan Bello (3-2, 3.31 ERA, 7.03 K/9)

Bello has been one of Boston's most reliable starters this season, and he appears to be really rounding into form this month, as evidenced by his 2.49 ERA over his last four starts. He turned in his best start of the season on June 15 against the New York Yankees, holding them to three hits and no runs over seven innings, and he followed that up by only allowing a single earned run over six innings against the Giants in his last start. Bello's 55% ground-ball rate ranks in the 91st percentile in baseball, as he throws an effective sinker and sweeper to keep the ball out of the air.
<h2>Notable injuries</h2>
Pitchers Ryan Burr (shoulder), Bowden Francis (shoulder), and Yimi Garcia (shoulder) are all on the injured list for Toronto. Outfielders Daulton Varsho (hamstring) and Anthony Santander (shoulder) are also on the shelf. As previously mentioned, Guerrero Jr. is day-to-day with an arm contusion.

Pitchers Tanner Houck (elbow), Jordan Hicks (toe), Kutter Crawford (wrist), Justin Slaten (shoulder), Hunter Dobbins (elbow), and Liam Hendriks (hip) are on the injured list for Boston. Third baseman Alex Bregman (quad), outfielder Masataka Yoshida (shoulder), and first baseman Triston Casas (knee) are also on the shelf.
<h2>Weather</h2>
Forecasts are calling for evening temperatures around 19 C under cloudy skies in Boston. Winds will blow from right field to left field at 8 mph.
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<h2>Blue Jays vs. Red Sox betting trends</h2>
<ul>
 	<li>The under is 7-3 in the past 10 meetings between these two teams.</li>
 	<li>The under is 10-4 in Boston's last 14 games.</li>
 	<li>The Blue Jays have hit the team total over in 18 of their last 25 games.</li>
 	<li>The Red Sox are 5-0 SU in their last five home games.</li>
</ul>
<h2>Blue Jays vs. Red Sox player prop trends</h2>
<ul>
 	<li>Bello has struck out four or more batters in four straight starts and seven of his last 10. He's around -115 to record over 3.5 strikeouts.</li>
 	<li>George Springer and Myles Straw are both bringing five-game hitting streaks into action. Springer is -215 to get a hit; Straw is -155.</li>
 	<li>Bello has recorded over 17.5 outs in each of his last four starts. He's -150 to do it again Friday.</li>
 	<li>Berrios has allowed under 5.5 hits in seven of his last 10 starts, averaging 4.9 hits allowed per game during that span. He's -110 to come under that number against the Red Sox on Friday.</li>
 	<li>Guerrero Jr. has incredible splits against Bello, boasting a .417 batting average with a 1.272 OPS in 24 at-bats against the right-hander. Vladdy also has two homers and 10 RBIs against Bello, but it's not a given he'll be in the lineup Friday due to his injury. Even if he does play, he might not be as effective at the plate if his arm is bothering him.</li>
</ul>
<h2>Blue Jays vs. Red Sox best bet</h2>
<ul>
 	<li><strong>Jarren Duran over 1.5 hits: +180 for one unit (best odds @ FanDuel)</strong>. Duran has been relatively quiet at the plate lately, but this seems like an excellent opportunity for him to break out against Berrios, a pitcher he's had a ton of success hitting against. Duran owns a .476 batting average and 1.619 OPS with three homers in 21 career at-bats against the righty, and he's recorded multiple hits in 38% of his games at Fenway Park this season. That means we're getting good value in this spot at +180 (35.7% implied odds), especially considering the batter vs. starting pitcher splits.</li>
</ul>

MLB betting preview (June 27): Blue Jays vs. Red Sox predictions

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