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MLB betting preview (June 6): Blue Jays vs. Twins predictions
Toronto Blue Jays shortstop Bo Bichette (11) hits a double against the Philadelphia Phillies in the sixth inning at Rogers Centre.
Photo credit: Dan Hamilton-Imagn Images
Greg Warren
Jun 6, 2025, 14:21 EDTUpdated: Jun 6, 2025, 23:59 EDT
Fresh off three consecutive series wins, the Toronto Blue Jays will open a nine-game road trip on Friday in Minnesota as part of a three-game set with the Twins.
Toronto took two of three from the Philadelphia Phillies at Rogers Centre earlier this week after completing a four-game sweep of the Athletics and taking two of three from the Rangers in Texas.
The Twins, meanwhile, took three of four from the Athletics earlier this week in Sacramento and will now return home for a six-game homestand.
Let’s take a look at the game odds for Friday’s series opener between the Blue Jays and Twins courtesy of bet365.

Blue Jays vs. Twins odds

Blue Jays moneyline odds
+130
Twins moneyline odds
-155
Runline odds
Twins -1.5 (+140), Blue Jays +1.5 (-165)
Game total
Over 8.5 runs (-110), Under 8.5 (-110)
Date/Time
June 6, 8:10 p.m. ET

About the Blue Jays (33-29 SU, 38-24 ATS, 31-30-1 o/u)

The Blue Jays have struggled to score runs all season long, but that wasn’t the case during their last seven-game homestand when they averaged 7.57 runs per game with a .394 on-base percentage, .968 OPS, and a .452 average with runners in scoring position.
Now, the challenge will be to replicate that kind of offensive production on the road. Toronto’s .641 team OPS away from Rogers Centre ranks 27th in the majors, and its 15 homers across 27 road games rank dead last in baseball.
Vladimir Guerrero Jr. went 0-for-5 on Thursday, ending his incredible 34-game streak of reaching base safely. He slashed a very impressive .291/.413/.456 in May with five homers and 12 RBIs.

About the Twins (34-28 SU, 36-26 ATS, 22-36-4 o/u)

The Twins have cooled off a little bit since their 13-game winning streak from May 6-17, playing .500 baseball (8-8) over their last 16 games. However, 10 of those games were played on the road, where the Twins are just 16-20 overall this season. They’re a solid 18-8 straight up and 17-9 on the runline at home.
The Twins’ pitching staff carries a very respectable 3.47 ERA (seventh in the majors) into this series, and those numbers are even better at home, as their 2.75 ERA at Target Field ranks fourth in the majors. Twins pitchers average a little more than a strikeout per inning (9.2), which also ranks fourth in baseball.
Offensively, the team is being carried by Byron Buxton, who leads the team with 10 home runs and 37 RBIs. The oft-injured outfielder has only missed a handful of games due to injury this season, allowing him to reach his star potential through the first portion of the season.
Third baseman Royce Lewis has been a major disappointment for the Twins, slashing just .139/.218/.215 in 24 games, fuelling rumours he could be sent to the minors to figure things out.

Probable starting pitchers

Toronto: RHP Paxton Schultz (0-0, 1.84 ERA, 12.27 K/9)
Schultz will get the ball for Toronto after throwing 30 pitches against the Phillies on Tuesday in a relief role. The expectation is that lefty Eric Lauer will also be used in a bulk role, so don’t expect Schultz to throw more than a few innings. Schultz has allowed just three runs over 14 2/3 innings of work while striking out 20 batters this season.
Minnesota: RHP Bailey Ober (4-1, 3.48 ERA, 7.26 K/9)
Ober has been fantastic for the Twins, allowing three earned runs or less in 11 of his 12 starts. He owns a sparkling 2.32 ERA at home this season and a 2.25 ERA in his night starts. Ober doesn’t throw hard, as his fastball tops out at around 91 mph, but he does boast an elite walk rate (5.2%) and a chase rate (34.9%) that ranks in the 94th percentile in baseball.

Notable injuries

Pitchers Ryan Burr (shoulder), Nick Sandlin (lat), Yimi Garcia (shoulder), and Max Scherzer (thumb) are all on the injured list for the Blue Jays. Outfielder Anthony Santander (shoulder) and outfielder Daulton Varsho (hamstring) are also on the shelf.
Pitcher Pablo Lopez (teres major strain) is on the IL for the Twins, and shortstop Carlos Correa is day-to-day with a back injury. Bettors will want to monitor Correa’s status leading up to the first pitch.

Weather

Forecasts are calling for temperatures around 20 C under clear skies this evening in Minnesota. Winds will blow in from centre field at 5 mph.

Blue Jays vs. Twins betting trends

  • The over is 6-1 in Toronto’s last seven games.
  • The over is 5-2 in Minnesota’s last seven games.
  • The Blue Jays are the best team on the runline (38-24) in the majors.

Blue Jays vs. Twins player prop trends

  • Ober has gone under his line of 2.5 earned runs allowed in 9 of his 12 starts this season, averaging two per game during that span. He’s around -140 to stay under that mark on Friday.
  • Twins third baseman Brooks Lee is taking an eight-game hitting streak into action. He’s hitting .300 with five RBIs over the last seven days and is a steep -240 to record at least one hit.
  • Bo Bichette homered on Thursday and now has four in his last eight games. He’s around +600 to go deep.

Blue Jays vs. Twins best bet

  • Bo Bichette over 1.5 total bases: +107 for one unit (best odds @ Pinnacle). Bichette has cleared this line in two straight games, seven of his last 10, and at a 50% rate this season. He’s slashing .296/.321/.593 over the last seven days and has historically raked at Target Field, producing a .375 batting average with a 1.063 OPS in 11 career games (48 at-bats) at Target Field. He’s a modest 2-for-8 in his career against Ober, but he’s swinging the bat well right now, so we like his chances of recording an extra-base hit or multiple hits in this contest.

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